Identification of a high-affinity receptor for interleukin 1 alpha and interleukin 1 beta on cultured human rheumatoid synovial cells.
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منابع مشابه
Identification of a high-affinity receptor for native human interleukin 1 beta and interleukin 1 alpha on normal human lung fibroblasts
Native human IL-1 beta and IL-1 alpha stimulated prostaglandin E2 secretion by human embryonic lung fibroblasts at half-maximal concentrations of 3 +/- 1.2 pM (+/- SEM) and 10 +/- 2.3 pM, respectively. In contrast to the 20-50-fold lower affinities previously found for IL-1-R on 3T3 cells as well as murine and human lymphoblastoid lines, monoiodo 125I-IL-1 beta bound to normal human fibroblasts...
متن کاملDifferential effects of interleukin-1 alpha and interleukin-1 beta on human peripheral blood eosinophils.
Interleukin-1 (IL-1) plays a major role in the response to infection, inflammation, and immunological challenge. Eosinophils participate in the host response to parasitic infection and allergic and hypersensitivity diseases. The role of IL-1 in these disease states has not been extensively explored. We have reported that purified human monocyte derived IL-1 (mIL-1), a mixture of the two IL-1 fo...
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متن کاملIDENTIFICATION OF A HIGH-AFFINITY RECEPTOR FOR NATIVE HUMAN INTERLEUKIN 10 AND INTERLEUKIN I a ON NORMAL HUMAN LUNG FIBROBLASTS
While IL-1 was initially described as a lymphocyte-activating factor (1), subsequent studies (2, 3) have shown that IL-1 regulates a variety of nonlymphoid cells involved in the inflammatory response . Prominent among these are connective tissue cells . While early studies demonstrated the ability of IL-I to stimulate proliferation by human dermal fibroblasts (4-6) and collagenase production by...
متن کاملThe effects of dexamethasone and chlorpromazine on tumour necrosis factor-alpha, interleukin-1 beta, interleukin-1 receptor antagonist and interleukin-10 in human volunteers.
Tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) are pro-inflammatory cytokines that play an important role in severe infections, whereas IL-1 receptor antagonist (IL-1ra) and IL-10 are anti-inflammatory cytokines that counteract their effects. Chlorpromazine and dexamethasone protect mice against lethal endotoxaemia by decreasing circulating concentrations of TNF-alp...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1988
ISSN: 0021-9738
DOI: 10.1172/jci113614